What is ANCA-Associated Vasculitis (AAV)? | TAVNEOS® (avacopan)
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Approved Use: TAVNEOS® is a prescription medicine that is used with other medicines (such as glucocorticoids) to treat adults with severe

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Approved Use: TAVNEOS® is a prescription medicine that is used with other medicines (such as glucocorticoids) to treat adults with severe active anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (granulomatosis with polyangiitis [GPA], formerly known as Wegener’s granulomatosis, and microscopic polyangiitis [MPA]). It is not known if TAVNEOS is safe and effective in children under the age of 18.

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What is AAV?

ANCA-associated vasculitis (AAV) is a group of rare autoimmune diseases that affect blood vessels throughout your body

In AAV, inflammation of small- to medium-sized blood vessels leads to reduced blood flow and impaired organ function. It is not known what causes these diseases, but it is thought to be a combination of factors, including genetics and the environment.

Active disease means that you have signs and symptoms of the disease that are new, not getting better, or getting worse.*

Severe disease is defined as GPA or MPA with signs and symptoms that are organ- or life-threatening.

*This does not include signs and symptoms related to past damage.

What are GPA and MPA?

GPA and MPA are the 2 most common subtypes of AAV

Severe active GPA and MPA are serious but treatable. You and your doctor will decide on a treatment plan that is best for you.

granulomatosis-with-polyangiitis-mb

Granulomatosis with polyangiitis (GPA)

In GPA, immune cells clump together, forming what are known as granulomas. GPA also causes inflammation of the blood vessels. It can affect the whole body, but often affects the kidneys, lungs, sinuses, nose, ears, and throat.

Kidneys Lungs Nose Ears

Microscopic polyangiitis (MPA)

MPA shares many signs and symptoms with GPA, but does not include granulomas. MPA is more likely to affect the kidneys, and cause uncontrolled bleeding in the lungs.

Kidneys Lungs

Understanding Severe Active GPA and MPA

Join nephrologist Dr. Dia Waguespack as she discusses what it means to live with severe active GPA and MPA. Tune in to learn more about signs and symptoms, goals of care, and approaches and challenges to treatment of GPA and MPA.

What are the signs and symptoms?

Talk to your doctor if you are having issues in any of the areas listed below:*

Tap each body part to learn more

Eyes Irritated eyes, blurred vision Ears Hearing loss