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These diseases involve inflammation of the blood vessels, which reduces blood flow and could lead to impaired organ function. While your genetics and environment are thought to be contributing causes of these diseases, the exact cause isn’t known yet.
Active disease means that you have signs and/or symptoms of the disease that are new, not getting better, or getting worse.
Severe disease is defined as AAV with signs and/or symptoms that are organ- or life-threatening.
Severe active GPA and MPA are serious but treatable diseases. Your doctor will work with you to develop a treatment plan that suits your needs.
GPA happens when immune cells clump together, forming what are known as granulomas. This causes inflammation in the blood vessels. It can affect the whole body, but often affects the kidneys, lungs, sinuses, nose, ears, and throat.
MPA shares many symptoms with GPA, but can have a more severe impact on the kidneys. People with MPA may be at a higher risk of uncontrolled bleeding in their lungs.
Identifying the signs and symptoms of severe active GPA or MPA early can lead to a timely diagnosis that can help you and your doctor decide on a treatment plan to help manage your condition.