TAVNEOS Connect | TAVNEOS® (avacopan)

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Welcome to TAVNEOS Connect

We’re committed to helping you start and stay on TAVNEOS® (avacopan). That’s why we created
TAVNEOS Connect—a patient support program that was designed with you in mind.

Click below for a digital brochure to learn more.

Download TAVNEOS Connect Brochure

The TAVNEOS Connect Team is here to:

  • Help you understand your insurance benefits and assist eligible commercially-insured patients with
    their copay (see below)
  • Offer resources to help you learn about your therapy
  • Connect you with patient communities that can support you during your journey
  • Provide medication to eligible patients who do not have insurance and meet other program criteria
Enroll in TAVNEOS Connect

TAVNEOS Connect services are only available for eligible patients whose diagnosis is aligned to the indication statement on the Food and Drug Administration (FDA)-approved TAVNEOS label. Additional eligibility criteria may apply.

Questions?

Call the TAVNEOS Connect Team at:
1-833-828-6367 (choose option 2)

We’re available Monday through Friday
from 8 AM to 8 PM ET.

We may be able to help you with your copay

The TAVNEOS Connect Copay Program may help you lower your monthly out-of-pocket costs. Eligible commercially-insured patients may pay as little as $10 for a 30-day supply of TAVNEOS®.

Terms, conditions, and program maximums apply. Other restrictions may apply. This program is not open to patients receiving prescription reimbursement under any federal, state or government funded healthcare program, or for cash patients. This is not insurance or a guarantee of payment. No cash value. Void where prohibited by law.

You’re not alone

There are organizations who provide education, support, and resources that may help you or your loved one throughout
the journey with ANCA‑associated vasculitis. Visit the sites of these key organizations to learn more.

External Resources

National Kidney Foundation logo

The National Kidney Foundation is the leading organization in the U.S. dedicated to the awareness, prevention, and treatment of kidney disease.

Vasculitis Foundation logo

The Vasculitis Foundation supports, inspires, and empowers people and families living with vasculitis through a wide range of eduation, research, clinical, and awareness initiatives.

National Organization for Rare Disorders logo

NORD is a patient advocacy organization committed to the identification, treatment, and cure of rare disorders through programs of education, advocacy, research, and patient services.

Frequently Asked Questions

    • Anti-neutrophil cytoplasmic autoantibody (ANCA)‑associated vasculitis are a group of autoimmune diseases. An autoimmune disease occurs when something results in the loss of the body’s tolerance to the antigens present. Vasculitis is the inflammation of blood vessels.
    • The 2 most common sub-types of ANCA‑associated vasculitis are GPA (granulomatosis with polyangiitis, previously called Wegener’s granulomatosis) and MPA (microscopic polyangiitis).
    • In GPA, masses of tissue in response to inflammation called “granulomas” develop inside parts of the body. GPA typically involves the kidneys, lungs, ears, nose, and throat. If you have GPA, you may be at risk for serious complications, such as hearing loss, kidney damage, skin scarring, or blood clots.
    • MPA also affects the lungs and kidneys. However, unlike GPA, your ears, nose, and throat are less likely to be affected, and there is no granuloma formation. Aside from kidney and lung complications, those living with MPA may experience stomach or intestinal issues, nerve damage, and skin symptoms.
    • In people with ANCA‑associated vasculitis, antibodies cause the immune system to attack blood vessels. These attacks cause inflammation in the blood vessels, restricting blood flow. This, along with treatment for ANCA‑associated vasculitis, can damage vital organs and tissues in many different parts of the body, leading to serious complications such as kidney failure, respiratory issues, and skin problems.
    • ANCA‑associated vasculitis is caused by antibodies called anti‑neutrophil cytoplasmic antibodies, or ANCAs. ANCAs target and attack neutrophils, a type of immune cell.
    • When ANCAs attach to neutrophils, they “program” these cells to attack blood vessels in the body. These blood vessels become swollen and inflamed. This is how vasculitis—inflammation of the blood vessels—occurs.
    • There are two well-regarded national organizations from which you can learn more about ANCA‑associated vasculitis:
      • The Vasculitis Foundation may be reached by phone at 816-436-8211, or you can visit the website at vasculitisfoundation.org
      • The National Organization for Rare Disorders may be reached by phone at 1-800-999-6673, or you can visit the website at rarediseases.org
      • The National Kidney Foundation may be reached by phone at 1-855-653-2273, or you can visit the website at kidney.org
    • TAVNEOS is a prescription medicine that is used with other medicines (such as glucocorticoids) to treat adults with severe active anti‑neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (granulomatosis with polyangiitis [GPA], formerly known as Wegener’s granulomatosis, and microscopic polyangiitis [MPA]).
    • It is not known if TAVNEOS is safe and effective in children under the age of 18.
    • Talk to your healthcare provider to find out if TAVNEOS may be an option for you.
    • When neutrophils, a type of immune cell in the body, become activated, the activation leads to the production of a protein called C5a. C5a attaches itself to a receptor called the C5a receptor, or C5aR.
    • This process plays a role in worsening the inflammation of blood vessels in ANCA‑associated vasculitis.
    • Avacopan, the active ingredient in TAVNEOS, works by blocking the interaction between C5a and C5aR.
    • Your healthcare provider can help you better understand how TAVNEOS works in your body.
    • The precise mechanism by which TAVNEOS works in ANCA-associated vasculitis has not been definitively established.
  • TAVNEOS may cause serious side effects, including:
    • Liver problems. People taking TAVNEOS may have serious liver problems. Call your healthcare provider right away if you have unexplained symptoms such as:
      • yellowing of your skin or the white part of your eyes (jaundice)
      • dark or brown (tea colored) urine
      • pain on the upper right side of your stomach area (abdomen)
      • bleeding or bruising more easily than normal
      • feeling tired
      • loss of appetite
    • Your healthcare provider will do blood tests to check how well your liver is working before starting and during your treatment with TAVNEOS
    • Serious allergic reactions. TAVNEOS may cause serious allergic reactions. Stop taking TAVNEOS and get emergency medical help right away if you have any of the following signs of a serious allergic reaction:
      • shortness of breath or trouble breathing
      • swollen lips, tongue, throat, or face
      • trouble swallowing
      • chest pain
      • feeling dizzy or faint
      • moderate or severe abdominal pain or vomiting
    • Hepatitis B virus (HBV) reactivation. Before you take TAVNEOS, your healthcare provider will do blood tests to check for hepatitis B (HBV) infection. If you have had hepatitis B or are a carrier of hepatitis B virus, taking TAVNEOS could cause the virus to become an active infection again. Your healthcare provider may decide to stop TAVNEOS and any other medicines if you have active hepatitis B liver disease. Your healthcare provider will tell you if and when you can start taking TAVNEOS again. Your healthcare provider will monitor you for hepatitis B infection during and for six months after you stop taking TAVNEOS. Tell your healthcare provider right away if you get worsening tiredness or yellowing of your skin or white part of your eyes during treatment with TAVNEOS.
    • Serious infections. Serious infections can happen in people taking TAVNEOS, and these infections can lead to death. The most common serious infections with TAVNEOS were pneumonia and urinary tract infections. People with serious infections should not take TAVNEOS. Tell your healthcare provider right away if you have any symptoms of infection:
      • fever
      • cold symptoms, such as runny nose or sore throat that do not go away
      • flu symptoms, such as cough, tiredness, and body aches
      • earache or headache
      • pain during urination
      • cold sores in mouth or throat
      • cuts, scrapes, or incisions that are red, warm, swollen, or painful
    • The most common side effects of TAVNEOS include:
      • nausea
      • headache
      • high blood pressure
      • diarrhea
      • vomiting
      • rash
      • tiredness
      • stomach pain
      • dizziness
      • increase in blood creatinine
      • burning or prickling sensation
    • These are not all the possible side effects of TAVNEOS.
    • Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1‑800‑FDA‑1088.
    • Do not take TAVNEOS:
      • if you are allergic to avacopan or any of the other ingredients in TAVNEOS. See the end of the Medication Guide for a complete list of the ingredients in TAVNEOS.
      • Get medical help right away if you experience swollen lips, tongue, throat, trouble swallowing, or difficulty breathing.
        These could be signs of an allergic reaction. Do not take more of TAVNEOS until you have consulted with your healthcare provider.
    • Always speak with your healthcare provider about questions that you may have about your health and treatments, and to decide if TAVNEOS is the right treatment for you.
    • Before taking TAVNEOS tell your healthcare provider about all your medical conditions, including whether you:
      • have or have had abnormal liver blood tests.
      • have or have had liver problems.
      • have or think you may have hepatitis B or hepatitis C.
      • have an infection.
      • are pregnant or are planning to become pregnant. It is not known if TAVNEOS will harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant.
      • are breastfeeding or plan to breastfeed. It is not known if TAVNEOS can pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take TAVNEOS.
    • Tell your healthcare provider about all the other medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. TAVNEOS and certain other medicines may affect each other and cause side effects. Keep a list of the medicines you take and show it to your healthcare provider and pharmacist.
    • Some medicines should not be taken with TAVNEOS.
    • Your healthcare provider may prescribe other medicines to treat your disease.
    • Take TAVNEOS exactly as your healthcare provider tells you to take it. Do not stop taking TAVNEOS unless your healthcare provider tells you to.
    • Check with your healthcare provider or pharmacist if you are not sure.
    • Take 3 capsules of TAVNEOS 2 times daily (morning and evening) with food.
    • Your healthcare provider may tell you to take 3 capsules of TAVNEOS 1 time each day if you take certain medicines. Tell your healthcare provider about all the medicines you take.
    • Swallow the capsules whole with water. Do not crush, chew, or open the capsules.
    • If you miss a dose of TAVNEOS, do not take the missed dose. Take the next dose at your regular time. Do not double your next dose.
    • If you have taken too much TAVNEOS, call your doctor or a Poison Control Center, or go to the nearest hospital emergency room.
    • Make sure to talk to your healthcare provider about what you should avoid while taking TAVNEOS.
    • Always tell your healthcare provider about all the medicines you take. Your doctor may not prescribe TAVNEOS if you are taking certain other medications or may discontinue those medications.
    • If you miss a dose of TAVNEOS, do not take the missed dose. Take the next dose at your regular time. Do not double your next dose.
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Important Safety Information

What is the most important information I should know about TAVNEOS?

TAVNEOS can cause serious side effects, including:

  • Liver problems. People taking TAVNEOS may have serious liver problems. Call your healthcare provider right away if you have unexplained symptoms such as:
  • yellowing of your skin or the white part of your eyes (jaundice)
  • pain on the upper right side of your stomach area (abdomen)
  • feeling tired
  • dark or brown (tea colored) urine
  • bleeding or bruising more easily than normal
  • loss of appetite
  • yellowing of your skin or the white part of your eyes (jaundice)
  • dark or brown (tea colored) urine
  • pain on the upper right side of your stomach area (abdomen)
  • bleeding or bruising more easily than normal
  • feeling tired
  • loss of appetite

Your healthcare provider will do blood tests to check how well your liver is working before starting and during your treatment with TAVNEOS.

Do not take TAVNEOS if you are allergic to avacopan or any of the other ingredients in TAVNEOS.

  • Get medical help right away if you experience swollen lips, tongue, throat, trouble swallowing, or difficulty breathing. These could be signs of an allergic reaction. Do not take more TAVNEOS until you have consulted with your healthcare provider.

Before taking TAVNEOS, tell your healthcare provider about all your medical conditions, including if you:

  • have or have had abnormal liver blood tests.
  • have or have had liver problems.
  • have or think you may have hepatitis B or C.
  • have an infection.
  • are pregnant or are planning to become pregnant. It is not known if TAVNEOS will harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if TAVNEOS can pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take TAVNEOS.

Tell your healthcare provider about all the other medicines you take,

including prescription and over-the-counter medicines, vitamins, and herbal supplements. TAVNEOS and certain other medicines may affect each other and cause side effects. Keep a list of the medicines you take and show it to your healthcare provider and pharmacist.

  • Some medicines should not be taken with TAVNEOS.
  • Your healthcare provider may prescribe other medicines to treat your disease.

TAVNEOS may cause serious side effects, including:

  • Liver problems (see above).
  • Serious allergic reactions. Stop taking TAVNEOS and get emergency medical help right away if you have any of the following signs of a serious allergic reaction: shortness of breath or trouble breathing; swollen lips, tongue, throat, or face; trouble swallowing; chest pain; feeling dizzy or faint; moderate or severe abdominal pain, or vomiting.
  • Hepatitis B virus (HBV) reactivation. If you have had HBV or are a carrier of HBV, taking TAVNEOS could cause the virus to become an active infection again. Tell your healthcare provider right away if you get worsening tiredness or yellowing of your skin or the white part of your eyes during treatment with TAVNEOS.
  • Serious infections. Serious infections can happen in people taking TAVNEOS, and these infections can lead to death. The most common serious infections with TAVNEOS were pneumonia and urinary tract infections. People with serious infections should not take TAVNEOS. Tell your healthcare provider right away if you have any symptoms of infection: fever, cold symptoms that do not go away, flu symptoms, pain during urination, or other signs of infection.

The most common side effects of TAVNEOS include:

  • nausea, headache, high blood pressure, diarrhea, vomiting, rash, tiredness, stomach pain, dizziness, increase in blood creatinine, and burning or prickling sensation.

What is TAVNEOS?

TAVNEOS is a prescription medicine that is used with other medicines (such as glucocorticoids) to treat adults with severe active anti-neutrophil cytoplasmic autoantibody(ANCA)-associated vasculitis (granulomatosis with polyangiitis [GPA], formerly known as Wegener’s granulomatosis, and microscopic polyangiitis [MPA]).

It is not known if TAVNEOS is safe and effective in children under the age of 18.

These are not all the possible side effects of TAVNEOS. Call your doctor for medical advice about side effects. Please see the Full Prescribing Information and Medication Guide for further details.

TAVNEOS is available as a 10 mg capsule.

You are encouraged to report negative side effects to 1-833-828-6367 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-332-1088.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TAVNEOS?

TAVNEOS can cause serious side effects, including:

  • Liver problems. People taking TAVNEOS may have serious liver problems.
    Call your healthcare provider right away if you have unexplained symptoms such as:

What is TAVNEOS?

TAVNEOS is a prescription medicine that is used with other medicines (such as glucocorticoids) to treat adults with severe active